Whether disturbed neurocircuits also contribute to deteriorating β-cell dysfunction as obesity and its sequelae progress is an active area of investigation (27).
Neuro-psychological testing may be useful to provide objective measures of subtle deficits not found with routine bedside mental state examination and also to monitor the progress of these sequelae.
In bacterial meningitis, the percentage of cases that progress to neurological sequelae ranges from 16 to 38% in pneumococcal meningitis and from 3 to 21% in meningococcal meningitis [ 44- 46].
Most infections in women are asymptomatic, and untreated infections can progress to serious sequelae, such as pelvic inflammatory disease (PID), ectopic pregnancy, tubal infertility, and chronic pelvic pain (5, 6 ).
Unless reversed by effective treatment, these sequelae can progress and cause death.
Further clinical progress results in severe sequelae or even leads to death.
The primary clinical manifestation of an E. coli O157 H7 infection is hematic diarrhea that can progress into more severe sequelae of hemolytic-uremic syndrome and thrombocytopenic thrombotic purpura, which then can lead to renal failure and death [ 2- 4].
Because leptospirosis may progress rapidly with severe sequelae, this reemerging infection deserves consideration in febrile patients with a history of freshwater recreation, even in states with a low reported incidence of infection.
It is of variable severity, usually heals with mild or no sequelae, but may progress to blindness from retinal detachments or severe retinal scar formation.
Consequently, C. trachomatis untreated infections can progress leading to chronic severe sequelae, including pelvic inflammatory disease, ectopic pregnancy, and obstructive infertility [ 2].
It is of variable severity, usually heals with mild or no sequelae, but may progress in some infants to partial vision loss or blindness from retinal detachments or severe retinal scar formation [ 1].
