Exact(1)
This process was predicted to be slow (progressing over decades), and thus implied a functional importance for mutations arising early in life [42].
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RA is a complex, polygenic autoimmune disease that progresses over decades and involves many different cell types, including both resident and recruited cells.
Parkinson's disease (PD), an age-related neurodegenerative disorder, progresses over decades.
This recipe, along with the fresh, pretty chutney that is a wee nod to how food has progressed over the decades, really makes the most of the sweetness of langoustines; the deep meatiness of the mussels and the delicate brine flavour from the clams.
Although the comprehensive treatment strategy for GBM has continuously progressed over recent decades, patients with GBM still have an extremely poor prognosis with median survival of 14.6 months [ 35].
While the global response to the pandemic has progressed over the decades both in scale and in efforts to reach diverse and vulnerable groups, stigma and discrimination still follow affected individuals in many settings [ 17, 19- 21].
The drummer John Hollenbeck's work, in its changing form, textures and rhythms, seems to have absorbed most of Western art music and kept a light sense of humor; it has progressed over the decade into something you really ought to know.
Clinically, chronic traumatic encephalopathy is associated with behavioral changes, executive dysfunction, memory loss, and cognitive impairments that begin insidiously and progress slowly over decades.
Especially in attenuated phenotypes, a definite diagnosis may be delayed for years because early symptoms are difficult to recognize for physicians not familiar with the disease, since the disease progresses silently over decades.
Development of gastric cancer, in particular the intestinal type, is a multi-step process that progresses over decades through premalignant lesions in the gastric mucosa, such as atrophic gastritis, intestinal metaplasia, and dysplasia [2].
Disc degeneration is perhaps best defined as a cascade that begins with changes to the cellular microenvironment within the substructures of the disc that progresses over decades to structural breakdown and functional impairment (Freemont, 2009; Urban and Roberts, 2003).
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