Twelve years after diagnosis, after progressing on eight lines of therapy, the patient started single-agent carfilzomib and demonstrated disease progression after five cycles.
Two years after diagnosis, after progressing on three lines of therapy (having most recently received bortezomib and dexamethasone), the patient started treatment with carfilzomib, dexamethasone, and cyclophosphamide.
Eleven years after her MM diagnosis, after progressing on seven lines of therapy (most recently while receiving pomalidomide), the patient started carfilzomib 20 mg/m on days 1 and 2.
Eleven years after diagnosis, after progressing on seven lines of therapy (most recently while taking bortezomib, dexamethasone, thalidomide, cisplatin, doxorubicin, cyclophosphamide, and etoposide [VDT-(P ACE] therapy without cisplatinum), the patient started carfilzomib through a compassionate use program.
In the next couple of weeks, policymakers have to make progress on two fronts.
This week they met in Paris to measure progress on two big commitments made in 2005.
The recent rebel advances in the south have not been matched by parallel progress on two other fronts.
The militant group said the bombing was a reprisal for Israeli raids, still in progress, on two refugee camps in the West Bank.
"She's Got the Look" demonstrates a lack of progress on two fronts: feminism and, more crucial to the show's future, development of the reality-competition format.
Some fear the worst, imperiling progress on two issues in particular: arms control with Russia and an always elusive settlement between Israelis and Palestinians.
EAST RUTHERFORD, N.J., Nov. 15 - The Nets made progress on two fronts Tuesday night: they projected a defensive presence that had been absent in their last two games and went deep into their lineup for production.
