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The progressing elucidation of the underlying and overlapping molecular pathologies of several neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD), has resulted in new biomarkers, which are urgently needed for more accurate diagnosis and as possible endpoints for clinical trials with future neuropreventive strategies.
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As one of three major animal groups with segmentation, annelids are critical in any investigation of body plan evolution; we need to understand the composition and branching history of groups within the annelid radiation if we are to progress towards elucidation of the last common ancestor of bilaterians and evolution of segmentation.
Information concerning the applicability of various animal models to humans and progress toward elucidation of causative agents and mechanisms of action is presented.
Research and technological innovations over the past 10 years have made considerable progress in the elucidation of mechanisms of ND initiation and progression that lead to neurodegeneration.
The chapter focuses on progress toward the elucidation of specific metabolic pathways linked to key quality traits in rice.
This review summarizes recent progress in the elucidation of the structural enzymology of the sulphate reduction and cysteine biosynthesis pathways.
Regardless of recent progress in the elucidation of intervertebral disc (IVD) degeneration, the basic molecular characteristics that define a healthy human IVD are largely unknown.
Since the completion of the Arabidopsis genome, functional genomics approaches have enabled significant progress on the elucidation of glucosinolate biosynthesis, although in planta validation of candidate gene function often is hampered by time-consuming generation of knockout and overexpression lines in Arabidopsis.
Recent progress toward the elucidation of benzylisoquinoline alkaloid (BIA) metabolism has focused on a small number of model plant species.
In this regard there has been remarkable progress in the elucidation of receptors that drive their production as well as other inflammatory mediators.
Despite significant progress in the elucidation of the roles played by NF-κB in breast cancer stem cell expansion, some issues remain to be experimentally addressed.
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