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Indeed, continuation of trastuzumab exhibits activity even in patients progressing during prior trastuzumab-based therapies (Von Minckwitz et al, 2009).
Four patients (20%) obtained a stable disease (median 3.9 months) despite progressing during previous standard irinotecan schedule.
The study involved patients with histologically confirmed, measurable, or evaluable advanced prostatic adenocarcinoma progressing during hormonal therapy.
Of these, 299 were identified as progressing during the initial trastuzumab-based treatment, and 77 received vinorelbine-based therapy as first salvage treatment.
One-third of patients progressing during or after platinum-based induction chemotherapy for metastatic germ cell malignancy may be cured by repeated 'conventional' platinum-based chemotherapy.
In the phase III randomized Tropic trial, patients progressing during or after docetaxel were randomized to cabazitaxel 25 mg/m² or mitoxantrone 12 mg/m².
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