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Of the five patients treated at MTD and assessed for response, one patient had stable disease for 5.5 months before disease progression; the others progressed within 1 2 months.
In the phase II part of the study an interim analysis (IA) will be performed after treatment of 24 patients that reached 4-month progression free survival (PFS) or that progressed within the first 4 months.
The optimal predictor comprised of five genes, differentially expressed between patients who had progressed within 8 months and those who remained progression free at that time point, at a significance level of 0.00005 (random variance t-test).
Of 35 patients, 29 progressed within the follow-up period, 5 were alive and progression-free, and one patient died 28 weeks after initiation of BCNU with no data on progression available (omitted from analysis of progression free survival).
Of the 41 patients with tumours informative at 19q12, 75% of those with LOH progressed within 5 years of surgery, compared to a 5% progression rate among patients with tumours that retained both alleles (P=0.0023, Figure 3A ).
To identify clinically meaningful biomarkers of the response, the patients were considered to be responders if they achieved a complete or partial response according to RANO criteria [ 6] and presented more than 6-month progression-free survival (PFS); the patients were considered to be nonresponders if they progressed within 4 months.
Similar(5)
In fact, non-white skin or a foreign surname continue to be major impediments to progress within France.
You might also want to get a copy of your appraisal, which will be useful in showing how you are progressing within your role.
Then you'd progress within 10 years or so to fullblown Aids and an array of illnesses that would kill you.
My professional experience is of officers sitting behind desks for months, even years, unable to progress within their career or even resign from the police.
There is always room to progress within the company.
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