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About 10% of the patients who developed HFS progressed to grade 3. The application of lotions or moisturizers was useful for symptoms relief.
In fact, several studies have demonstrated that a proportion of patients with ASCUS and LSIL may progress to higher grade of dysplasia and even cancer [ 31- 33].
Crowley soon progressed through the grades of the Golden Dawn, and was ready to enter the inner Second Order.
In 45 elbows that had been graded as Larsen grade 4 preoperatively, 32 elbows remained at grade 4 and 13 elbows progressed to Larsen grade 5. Assessment of clinical mediolateral joint stability showed minimal instability (0 5°) in 59 elbows, moderate instability (6 10°) in 3 elbows, and marked instability (> 10°) in 2 elbows.
As HPV-associated koilocytes in the cervix may progress to varying grades of malignancy (Thomison et al, 2008), it follows that HPV may be causally associated with breast cancer.
In addition, histological examination and nuclear grading of the tumors revealed no significant differences in the percentages of tumors that had progressed to grade III, late-stage carcinoma (Fig. 4C, 8% of the MMTV-PyMT Mmp13−/− MMTV-PyMT Mmp13−/yMT;Mmp13+/+ tumors).
These events were typically low grade, rarely observed in more than one patient, with the exception of grade 3 headache that never progressed to grade 4.
Only 10.5% of the patients progressed to higher grading (mostly Los Angeles grade C) and none has progressed to Barrett's esophagus.
More recently, a study examining plasma exchange in ALF having progressed to grade 2 coma, with an etiology of largely acute and hyperacute patients showed a mortality benefit on intention to treat, with effect being largely observed in patients who did not proceed to transplantation [217].
Some type II tumours tend to progress to higher grades of malignancy, for example, low-grade diffuse astrocytomas that transform to anaplastic astrocytoma and glioblastoma.
They would progress through the grades of "ruby" and "emerald" to the ultimate "diamond" level.
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