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This study provided a relatively longer duration of follow-up and, despite its limitations, very few NERD patients progressed to develop esophageal mucosal injury.
At follow-up, only 51717%) of the NERD patients progressed to develop erosive esophagitis (all to grade 1 Savary-Miller).
In a publication by Pace et al.,14 which was a long-term follow-up of a previously published short-term follow-up study, the authors claimed that 94% of NERD patients progressed to develop erosive esophagitis after 5 years of follow-up.
Some of these subjects progressed to develop drug-induced autoimmune thrombocytopenia [ 6– 8].
Two patients progressed to develop visceral metastases, and one patient unfortunately succumbed to metastatic disease of bone, brain and viscera.
Control mice injected with the adenoX-lacZ control did not improve and progressed to develop a more severe arthritis.
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Atopy affects up to half of the adult population in developed countries; yet, the great majority do not progress to develop asthma [ 12].
Because most natural history studies suggest that the vast majority of NERD patients never progress to develop erosive esophagitis or Barrett's esophagus,81 therapeutic approaches such as on-demand or intermittent therapy are an attractive option for these patients.
These changes are dynamic; it has been reported that patients with preserved ventricular function may progress to develop severely depressed contractility [12].
Infants born infected with HIV (I), can later progress to develop AIDS (A).
1 A subset of patients with NASH may progress to develop cirrhosis and hepatocellular carcinoma.
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