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Evaluation of this combination therapy has progressed to a phase III trial [ 54].
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Semagacestat, the only γ-secretase inhibitor to reach a phase III trial so far, fared even worse.
A phase III trial comparing eribulin to dacarbazine in patients with intermediate to high-grade advanced liposarcoma or leiomyosarcoma who have progressed after standard therapy is ongoing.
Cunningham et al (2003) reported on a phase III trial randomising patients with colorectal cancer, who had progressed on irinotecan to cetuximab with or without irinotecan.
Prestwick Pharmaceuticals has recently completed a phase III trial using tetrabenazine to treat HD chorea.
A phase III trial revealed treatment with everolimus prolongs progression-free survival in patients with metastatic renal cell carcinoma that had progressed on other targeted therapies [ 22].
The new results are from a Phase III trial, typically the last stage before approval.
But Renovis suffered a significant setback last year when its lead drug candidate, a stroke treatment, failed a Phase III trial.
If the phase Ib study shows that the combination is active, a phase III trial will follow.
After successful Phase II clinical trial, a Phase III trial for AML has started in 2008.
Given the efficacy signal, a phase III trial is warranted.ClinicalTrials.gov NCT01661894.
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