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We further hypothesise that these PrPd-initiated morphological changes progress with increasing PrPd accumulation to more complex hypertrophic structures and excess immune complex retention as demonstrated by Ig labelling.
Also, it remains unclear at what age such changes start to arise in the population and at what rate they subsequently progress with increasing age.
The M-protein concentration time curves are similar in shape to tumour SLD time curves, with some patients appearing to progress with increasing M-protein concentrations after developing resistance, some patients responding to treatment with decreasing M-protein and some patients progressing directly from the start of the study.
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Osteoarthritis usually begins in the fourth decade of life and slowly progresses with increasing age.
In addition, the saponite chlorite conversion within C/S steadily progresses with increasing alteration of the host basalt rock.
Heterogeneous photocatalysis with TiO2 particulate has rapidly progressed with increasing interest in the photo-oxidative degradation of various organic contaminants.
New technology developments that can be used to target the specificity and efficacy of new drug treatments within the health care system is progressing with increasing successes, in both Japan, North America and Europe.
Ultrastructural changes in the kidney of crucian carp progressed with increasing accumulated MCs and exposure times within 48 h post-injection, whereas renal ultrastructural recovery of crucian carp in the 50 μg MC-LReq.
We chose to use echocardiography to evaluate cardiac function because we can see evidence of dysfunction as early as 15 months of age in C57BL/6 wild type mice, which continually progresses with increasing age (Dai et al., 2009).
Insulin deficiency progresses with increasing age, but is seldom absolute in CF and ketoacidosis is uncommon [ 7].
These data suggest that IENF loss is an early feature of diabetes, progresses with increasing neuropathic severity, and may repair with early intervention.
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