If the accumulation of LDL cholesterol progresses unchecked, atherosclerotic plaques will form as a result of increased number of proliferating smooth muscle cells (SMCs) and extracellular lipid.
Although the control of disease activity in RA is better today than in the past, vasculitis is still a problem for some patients and is likely to persist in health care systems and parts of the world where access to current therapy may be limited and disease progresses unchecked.
In the interiors of Maharashtra, those affected lack access to timely intervention and are often forced out of their villages with the onset of the physical deformities that mark the disease's unchecked progress.
We propose that loss of Rb function in the evolution of NPM-ALK+ ALCL may be sufficient to counteract NPM-ALK-induced activation of cell-cycle checkpoints, permitting unabated and unchecked progress through the cell cycle.
Understanding the Unabomber: Had his career not tipped into violence, terror and ultimately murder, would the ideas of Ted Kaczynski, aka The Unabomber, deserve a place in the lineage of reasonable opposition to unchecked technological progress, from Aristotle to Jacques Ellul?
Based on the results of this study, in the absence of an effective oral care regime periodontitis will develop rapidly in this breed and if left unchecked could progress further and ultimately lead to loss of teeth and significant discomfort for the dog [ 7, 16].
With unchecked progressive secondary hemorrhage, hematoma expansion can occur.
