Details of the PROGRESS trial have been described previously.
More recently, the Perindopril Protection Against Recurrent Stroke Study (PROGRESS) trial confirmed the benefits of blood pressure lowering in secondary prevention (PROGRESS 2001).
The TSC then meets regularly to discuss issues such as recruitment progress, trial implementation data, and indications of protocol deviations.
Active treatment also reduced the odds of disability by 24% (P<0.001) and dependency ("requirement of regular help with everyday activities") by 16% (P=0.04) in the PROGRESS trial (PROGRESS 2003c).
In-progress trials must affirm the results of the trials used to justify a stringent goal for L.D.L. cholesterol, the "bad" cholesterol, of less than 70 in the highest-risk patients.
We contacted researchers at the London School of Hygiene and Tropical Medicine who were authors of some of the included and in-progress trials, and other experts in the field of malaria chemotherapy, including those based at WHO.
Frustrated by the slow progress of trials, they suggested abandoning the placebo in favour of other forms of clinical trial that could fast-track treatments.
He argued that they would slow down the progress of trials and would be too expensive.
There has been more progress on trials transparency in the past 12 months than in the past 25 years.
BMS's revenues, like AstraZeneca's, are still roughly flat, but the excitement is generated by the progress in trials of potential cancer drugs.
