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Details of the PROGRESS trial have been described previously.
The TSC then meets regularly to discuss issues such as recruitment progress, trial implementation data, and indications of protocol deviations.
More recently, the Perindopril Protection Against Recurrent Stroke Study (PROGRESS) trial confirmed the benefits of blood pressure lowering in secondary prevention (PROGRESS 2001).
157 A post-hoc analysis in the PROGRESS trial showed that dementia incidence in patients with recurring stroke was reduced by 34% when treated with antihypertensives.
Active treatment also reduced the odds of disability by 24% (P<0.001) and dependency ("requirement of regular help with everyday activities") by 16% (P=0.04) in the PROGRESS trial (PROGRESS 2003c).
Secondary analyses of data between two large clinical trials to reduce the incidence of stroke – the Systolic Hypertension in Europe (SYST-EUR) trial (involving the ACE-I enalapril) and the Perindopril Protection Against Recurrent Stroke Study (PROGRESS) trial (involving the ACE-I perindopril) – found that the ACE-Is reduced dementia and cognitive decline [ 8].
Similar(52)
For secondary stroke prevention, both the PATS and Perindopril Protection Against Recurrent Stroke Study (PROGRESS) trials suggested that lowering of blood pressure with either indapamide alone or indapamide+perindopril was as effective or even more so in Asian populations.
In-progress trials must affirm the results of the trials used to justify a stringent goal for L.D.L. cholesterol, the "bad" cholesterol, of less than 70 in the highest-risk patients.
We contacted researchers at the London School of Hygiene and Tropical Medicine who were authors of some of the included and in-progress trials, and other experts in the field of malaria chemotherapy, including those based at WHO.
A prospective study is in progress (clinical trial.gov NCT01890317).gov NCT01890317
Those concerns seem to have been relieved by September 2013, when the Metropolitan Police told Hacking Team it was "ready to progress the trial" of a spying tool.
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