Sentence examples for progress toward senescence from inspiring English sources

Cell size is progressively increased in cell culture as cells progress toward senescence [ 54- 56].

Nampt activity has been shown to decline as cells progress toward senescence [ 71– 71].

As a result, chondrocytes from osteoarthritic patients might progress toward senescence more rapidly than those from normal individuals.

A typical feature of senescent cells is that they are large-sized (hypertrophic), also it is well known that cell size increases in culture as cells progress toward senescence [ 76].

As a cell progresses towards senescence, cellular ROS levels increase, resulting in electron transport chain dysfunction and a drop in mitochondrial membrane potential (MMP 26.

MEFs taken from H2AX-null mice progress similarly toward senescence and senescent H2AX-null MEF cells exhibit characteristics similar to those from wild-type mice (data not shown).

Here, we examined global gene expression by analyzing a time-course as IMR90 cells progressed toward senescence.

Using the cells described in Fig. 3(A,B), the levels of let-7a, miR-30, U6, as well as p66Shc mRNA levels in 2BS and IDH4 cells progressing toward senescence were determined by Northern blot analysis (Fig. 3D) and by conventional RT-PCR analysis (Fig. 3E) respectively.

These results indicate that as human fibroblasts are passaged in vitro and progress toward replicative senescence, SIRT1 protein expression is significantly downregulated.

Here, we show that SIRT1 levels decline with passage number in vitro as IMR-90 and WI-38 normal human fibroblasts progress toward replicative senescence (Fig. 4A and B).

Expression changes were exacerbated with a progression toward senescence, pointing toward regulation of specific pathways (Fig. 1B).