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Therefore, the residual PKB activity present in PKBα−/− thymocytes might be sufficient to permit thymocytes to progress to mature T cells despite accumulation of early thymocyte subsets at the DN to DP transition.
Second, the progress to mature schizont stages was marked by significant increase in transcription of genes associated with essentially all functionalities involved in protein metabolism.
Constitutive activation of β-catenin during development leads to uncontrolled placode formation, but the placodes do not progress to mature HFs or express adult stem cell markers such as Sox9, K15 and Lrig1 (Narhi et al, 2008; Zhang et al, 2008).
In sharp contrast, we could not detect any GFP DNA signal in sperm genomic DNA prepared from mice transduced with either Rad1 or Xrcc2 vector, indicating that spermatids expressing exogenous piRNA-resistant Rad1 or Xrcc2 failed to progress to mature sperm.
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Parasites were cultured for 72 h through to the next cycle when most parasites progressed to mature trophozoites.
Another previously developed model, where hAPP is also expressed under the control of the PrP promoter, displays even earlier onset of amyloid deposition, starting at 3 months and progressing to mature plaques and neuritic pathology from 5 months of age, accompanied by high levels of Aβ1 42 (Chishti et al. 2001).
Only C-capsids progress directly to mature virions.
Possibly, NF-κB-deficient precursor cells progress less efficiently to mature Tregs than their wild-type counterparts.
The development of full C4 capacity progresses from early to mature developmental stages, as structural characteristics and expression patterns for genes encoding various photosynthetic enzymes diverge between the two cell types.
The diversity of these transcripts is greatly decreased as the pollen progresses from uni-cellular microspores to mature grains (Wei et al. 2010).
Moreover, it is well conceivable that the mCLCA5 protein in mucus cells and ciliated cells is lost with progressing differentiation from airway precursor to mature cells.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com