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In nearly 10% of cases, this infection persists and is associated after 5 to 10 years with lesions that may regress, remain stable or progress to a higher grade and invasive cancer.
Although this study shows only fair agreement between the grade of the original DCIS and that of the subsequent invasive tumour, there is no suggestion in this or the EORTC study that low-grade lesions often progress to a higher grade.
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Patients with a WHO grade II oligodendroglioma may survive even longer, but sooner or later such tumors generally progress to a high-grade malignant glioma as well.
We and others have shown that the expression of ERβ in human prostate epithelial cells decreases as PCa develops and progresses to a higher grade (Leav et al. 2001, Zhu et al. 2004), but reappears in the lymph node and bone metastases (Lai et al. 2004, Zhu et al. 2004).
He developed asymptomatic Wenckebach which progressed to a high-grade second-degree AV block (Fig. 3).
In a previous study, a proportion of patients with low-grade stress fractures were found to recover under ongoing stress, while in others the injury progressed to a high-grade fracture [ 8].
It was, however, difficult to wean students off the instant gratification of grades and some were still concerned that progress should be linked to a higher grade and were disappointed if this did not happen.
Our findings suggest that WHO grade II astrocytomas with a high Ki-67 LI or TP53 expression are more likely to progress to higher grade astrocytomas.
This may reflect an overall shift to a greater state of methylation within promoter CpG islands as the tumour progresses towards a higher grade.
Some type II tumours tend to progress to higher grades of malignancy, for example, low-grade diffuse astrocytomas that transform to anaplastic astrocytoma and glioblastoma.
Advances in magnetic resonance imaging (MRI), combined with a longitudinal human trial [ 3], have shown that cartilage defects often progress to large, higher grade lesions over time, ultimately resulting in osteoarthritis.
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