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Despite significant progress, the functional importance of DNA methylation in Drosophila remains controversial, and important mechanistic aspects of the DNA methylation process remain unknown [4], [7] [8].
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This chapter summarizes research progress in the functional modifications of polymers, fibers, and textile materials.
Lacking of an efficient expression system that produces sufficient amounts of active and homogenous receptors hinders progress in the functional and structural characterization of the 5-HT2c receptor.
There was no significant progress in the functional walk test (6MWD).
Indeed, despite dramatic progress in the "functional" cure of HIV infection, we have failed to eradicate virus from the infected organism.
Despite recent progress on the functional identification of aquaporins [ 59- 61], the contribution of each aquaporin protein on substrate uptake and plant physiology remains to be elucidated.
In addition, recent progress in the functional imaging and monitoring of biomarkers during treatment have provided the basis for a risk-adapted therapy approach that is currently being tested in clinical trials.
Notwithstanding cumulative progress in the functional characterization of EPCs using genome-wide expression profiling [ 1, 5], there is a lack of systems-level understanding of key interactions and processes controlling the response of EPCs to candidate therapeutic interventions.
Further progress in the functional characterization of these intricate proteins, which probably have important roles in human cancer, should help us to improve human cancer diagnosis and prognosis, and to develop more effective therapeutic strategies.
This recent progress underlies the functional role of miRNA in cellular transformation of liver cancer, which has largely extended our knowledge how HSCs are controlled by miRNA network, and in the development of novel miRNA-based anticancer therapies specifically targeting HSCs in the coming future.
Evolutionary conservation may be frustratingly silent on the nature of the functions it highlights, but progress in understanding the functional significance of DNA sequences can only be achieved by not ignoring evolutionary principles.
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