Our patient illustrates two current concepts about Lynch syndrome: 1) adenomas are the cancer precursor and 2) such adenomas may be "aggressive," in the sense that the adenoma progresses more readily and more rapidly to carcinoma in this setting compared to usual colorectal adenomas.
For example, a recent study in a squamous cell carcinoma model showed that epidermis-specific deletion of α3β1 (i.e., using a conditional α3-knockout model) led to reduced skin tumorigenesis, whereas tumors that did form in these mice progressed more readily to invasive carcinoma, indicating opposing roles for α3β1 in early and late stages of skin carcinogenesis [ 54].
Prior studies have demonstrated that RB loss can alter DNA ploidy in the presence of DNA damage, and tetraploid p53-deficient cells can readily progress to an oncogenic phenotype [57], [58], [59], [60].
The reasons for this are unclear, but as only ~50% of patients with Candida esophagitis have concurrent OPC, it is possible (and supported by our data; Figure 3) that RA patients may have elevated rates of subclinical C. albicans colonization, and hence are poised to more readily progress to clinical OPC under certain circumstances; for example, targeted anti-IL-17A therapies.
Released cultures of untreated AGS readily progressed through G1 into S and G2/M phases [22], whereas 5-FU-treated cells remained in G1 phase (not shown).
Thanks to a few decades of remarkable and relentless engineering progress, miniaturized components are readily available that allow whole new species of powerful mobile and wearable technologies.
These results suggest that SIC seropositive CKD patients may progress to ESRD more readily than the SIC seronegative CKD patients.
At 19 weeks after the first NNK injection when the adenoma is expected to be induced at 100% incidence and readily to progress to adenocarcinoma, mice were randomly separated into the control and EGCG treatment groups (15 per group).
Yamada, along with Fisheries Agency Counselor Joji Morishita and Assistant Director of the Far Seas Fisheries Division Toshinori Uoya, readily acknowledged that progress in talks in Santiago presented an opportunity to move forward in the IWC.
This is in accordance with the view of TPACK as a holistic and transformative form of knowledge suggesting that growth in just one of the three knowledge bases, i.e., technology, content, and pedagogy, does not readily bring about progress or growth in TPACK as a whole (Angeli & Valanides, 2009).
