As you review the literature to provide rationale for your study, progress through what is known to what is unknown, indicating the gaps in or limitations of the current work, orchestrating the information so that it is clear why your study is important... because it will plug those holes and address those limitations, of course.
S. aureus osteomyelitis is known to progress without the presence of the cement block [16, 18], and if left in place, it may induce an uncontrollable progress of S. aureus infection into fatal sepsis.
Despite the great progress in nanotechnologies, comparatively little is known to date on the effects that exposure to NPs may have on the human body, in general and specifically on the brain.
The cognitive decline arising from human AD or VCI is known to progress over a period of decades.
In addition, the severity of existing dental erosion cases is known to progress steadily [ 40].
MBL is known to progress to CLL in approximately 2% of cases, and CLL may generally be preceded by MBL.
Long term chronic gastritis associated with H. pylori is known to progress to glandular atrophy and intestinal metaplasia (IM) over a period of 12 years [ 3].
In AD, Tau-pathology is known to progress according to stereotypical and predictable patterns reflected in its incorporation in criteria for the neuropathological diagnosis of AD [ 6, 34].
Renal impairment is known to progress over time (Hillmen et al, 2010) and is associated with an increase in mortality (Kim et al, 2011).
19 Likewise, ocular amyloidosis is known to progress after liver transplantation, presumably due to the fact that the retinal pigment epithelium continues to synthesize vTTR even after liver transplantation.
