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In 1999 the journal Nature Genetics dedicated a special issue to DNA microarrays with an introductory essay entitled "Array of hope .Meanwhile, progress in sequencing the human genome was generating enormous excitement in the bioscience industry.
Rapid progress in sequencing eukaryotic species has enabled the recent phylogenetic profiling of the human genome, resulting in systematic functional predictions for uncharacterized human genes.
Despite the progress in sequencing technology, however, Poinar says he's frustrated that the tools for preparing the samples have hardly changed.
Progress in sequencing technology and the mechanistic understanding of secondary metabolite pathways has led to the discovery of many formerly cryptic natural products and a molecular understanding of their assembly.
In addition, progress in sequencing technology has allowed mutational analysis of more than 10,000 genes in a single individual and has accelerated research on disease-associated allelic variations at the whole genome sequencing level [2].
Current progress in sequencing technologies accelerates the accumulation of completely sequenced genomes: 1,139 Prokaryotic and 129 Eukaryotic genomes are now available as of this writing (6th May, 2010) according to the GOLD database [24].
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Progresses in sequencing HS chains and reproducing them either by chemical synthesis or semi-synthesis, and in the elucidation of the 3D structure of oligosaccharide protein complexes, are paving the way for rational approaches to the development of HS-inspired drugs in the field of inflammation and cancer, as well in other therapeutic fields.
Recent progress in sequence alignment and structure prediction has suggested the importance of variable gap penalties in protein sequence alignment [51].
While large-size inversions (macroscopic inversions), microscopically-detectable and/or visible in genetic maps, were identified early on [ 1, 3], the recent abundance of genomic sequences and progress in sequence analysis has enabled the extensive detection of inversions of various sizes in genomes.
Because of recent rapid progress in nucleotide sequencing, the whole-genome sequences of not only human but also great apes have become available (Chimpanzee Sequencing and Analysis Consortium 2005; Locke et al. 2011; Scally et al. 2012).
The rapid progress made in sequencing and molecular-marker technology is now beginning to change the way breeding is done, providing new opportunities.
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