However, the differences where profound when we compared progressing sites at baseline with the breakdown time point and even more profound when we compared the two baseline samples from progressing and non-progressing sites.
First, the frequency of joint swelling was compared between the progressed and non-progressed joint at baseline and at each following 12-month interval.
Other members of the community, usually not considered pathogens, showed a large number of putative virulence factors being upregulated during periodontitis progression and at baseline of progressing sites.
Similarly, the reasons why the majority of patients did not progress, despite autoantibodies at baseline, are also unclear, but may be of importance to understanding pathogenesis.
Interestingly, members of the red complex showed enrichment in response to antibiotics (beta-lactamase activity) during progression and even at baseline of progressing sites.
We collected one stable site and one progressing site, both at baseline and at the endpoint of analysis.
It seems likely that the more degenerated joints at baseline progress differently than a joint in the early phase of the disease.
Patients with low systolic perfusion pressure at baseline progressed faster than their counterparts.
In contrast, 9% of participants with early retinopathy at baseline progressed to PDR over 4 years.
In our study, 2 household contacts who were QFT-GIT test negative at baseline progressed to active pulmonary TB.
