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The experiments were designed to allow us to answer the following questions: (i) To what extent are leukaemia initiation programmes induced by MLL-ENL and MOZ-TIF2 distinct?
The gene expression programmes induced by ST and by EGF alone were dramatically different over the 72 h period in PMC42-LA cells when examined by MT-PCR.
Intriguingly, hyper-activation of LIF signalling can even override the programmes induced by Activin and FGF in EpiSC, to promote the generation of chimaera-competent ES-like cells [ 55 ].
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Because, for the serfs, all those property programmes induce a poisonous envy and resentment.
This indicates the essential role of these two MAPKs in priming the apoptotic programme induced by the drug.
Inhibition of H3K9me2 may disrupt the apoptotic cell death programme induced by aminoglycosides and thus prevents hair cell loss.
The ART programme induced firmer referral linkages between CHBC programmes and health facilities in the four countries but variable institutionalisation of collaboration.
The first programme is a thrifty hepatic metabolic programme induced by early life growth restriction, governing the efficiency with which fuel is used by the body.
We then asked whether blocking this increase of H3K9me2 level can suppress the onset of the apoptotic programme induced by aminoglycoside and prevent the consequent hair cell death.
Interestingly, the transcriptional programme regulated by HSF1 in highly malignant tumours is distinct from the heat shock programme induced by thermal stress, but are commonly activated in a range of human malignancies (lung, breast and colon cancers).
These results suggest that sustained activation of JNK and p38 is essential for triggering the apoptotic programme induced by APL and that HeLa-APL cells bypass this apoptotic response by preventing the specific mechanisms that prime and sustain the long-term activation of these signalling cascades.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com