Key lessons include the need to develop skills to understand program mechanisms and contexts, recognize multiple models of causality, apply mixed method designs, and ensure the successful scaling up and spread of an intervention.
Observations, documentary analysis, interviews and group discussions with 19 participants were utilized to develop a detailed understanding of the program mechanisms, activities and processes, as well as the experiences of key stakeholders engaged with the funding scheme and its implementation.
He is the principal investigator for the Director's Challenge Program "Mechanisms of Susceptibility to Oxidative Stress Induced Disease".
Financial support was provided by the Deutsche Forschungsgemeinschaft (SPP1230 priority program "Mechanisms of gene vector entry and persistence" and Excellence cluster ("NIM").
Financial support by the Deutsche Forschungsgemeinschaft BAA 2035/3-1 and SPP1230 priority program "Mechanisms of gene vector entry and persistence") and the Bundesministerium fuer Bildung und Forschung (BMBF BioChancePLUS/FKZ: 0315182) to AB is gratefully acknowledged.
Piwi deficiency drastically changed the epigenetic landscape and polymerase II profile throughout the genome, revealing the Piwi-piRNA mechanism as a major epigenetic programming mechanism in Drosophila.
Kepler compute architecture based GPU (Tesla K40) with Compute Unified Device Architecture (CUDA), which is a parallel programming mechanism for GPU is used in the development of the detection algorithms.
The present study was designed to demonstrate that prenatal ethanol exposure (PEE) could enhance the susceptibility of high-fat diet-induced metabolic syndrome (MS) in adult male offspring via a hypothalamic pituitary adrenal (HPA) axis-associated neuroendocrine metabolic programmed mechanism.
Activity driven refinement of local neural networks, through synaptic plasticity and axon remodeling, is ubiquitous in developing neural systems, and is a necessary supplement to the genetically programmed mechanism of laying out coarse connections between brain areas [13], [14].
Apoptosis is a genetically programmed mechanism for induction of cell death.
