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The normalized Fay and Wu's H statistic [18] was calculated with a program kindly provided by S. E. Ramos-Onsins.
Data acquisition and analysis were performed with a program kindly provided by Dr. John Dempster (University of Strathclyde, Scotland).
(e.g. Fig. 1a) Area measurements and volume reconstructions were performed by an experimentally blind observer using a custom computer program kindly provided by R. Wolf and M. Heisenberg, Univ.
The D∥/D⊥ ratio of the rotational diffusion tensor for the I214V mutant of RaPrPC(121 228) was calculated to be 1.24±0.01 using the r2r1_diffusion program (kindly provided by Prof. A.G. Palmer 3rd), suggesting that the axially symmetric model is suitable for the data fitting.
All analyses were conducted with a program kindly provided by Kai Zeng.
ENC-X scores were estimated using the 'cusage' program kindly provided by Etsuko Moriyama.
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We did the analyses using scripts and programs kindly provided by the group of Prof. Liberles.
The ASNN program was kindly provided by Dr. Igor Tetko.
It was computed using the software program Programita kindly provided by Thorsten Wiegand.
Pituitaries were homogenised in phosphate-buffer saline and assayed for anterior pituitary hormones using National Hormone and Pituitary Program reagents kindly provided by A.L. Parlow, as described in [25].
The GenBank documents were processed by the program "CleanUP", kindly provided by the Department of Biochemistry and Molecular Biology, University of Bari, Italy [ 62].
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