However, others consider that, as a prognostic indicator, PR is still worth assessing (MacGrogan et al, 2005).
A subjective well-being and a feeling that life is worth living may represent prognostic factors for longevity and healthy aging in the later stages of life.
By doing so, we could demonstrate that the SUV was surely worth considering as a prognostic factor in patients with liver metastases.
For example, some journals require the prospective registration of randomised controlled trials (De Angelis et al, 2004), and this is an option worth exploring further for prognostic studies.
It seems worth investigating further the prognostic impact in a larger cohort of patients as it might have long-term implications in selecting patients who will do badly with standard treatment and might benefit from integrin modulation therapy.
However, it is worth mentioning that the prognostic information obtained by Ki-67LI in luminal tumors is equivalent to or even greater (in terms of HR) than that provided by MS alone and than that provided by histologic grade or HER2 or PR status.
As ALF is a devasting clinical condition, it is worth it to evaluate new prognostic tools to improve outcome in this patients.
Although the difference is not statistically significant, it is worth noting that adverse EC prognostic indicators such as high histological grade (G3) and extensive (>50%) myometrial invasion were observed only in subjects with AUB at diagnosis: this might suggest delayed detection being associated with AUB, but this finding is based on a few cases and needs to be confirmed on a larger EC series.
Anemia during therapy (hemoglobin nadir) is worth to be considered as a prognostic factor because it frequently is a consequence of the therapy modality (surgery, chemotherapy).
It is worth noting that SCS, as a new prognostic determinant, appeared as efficient as stage grouping in defining outcome and seems to replace the CCI most likely as a result of redundancy of the prognostic information.
