A potential limitation of this study is the retrospective nature of the collection of both cohorts; a prognostic trial of a single marker such as this can rarely be prospectively designed outside the setting of a clinical trial.
We selected the gene modules that have significant association with tumor progression by applying t-test in multiple prognostic clinical trials.
24 We now know from prognostic studies and trials that high compression therapy heals some 80% of venous ulcers within 12 months and that ulcers smaller than 5 cm and of less than six months' duration are likely to heal quickly.
Chronic obstructive pulmonary disease (COPD) is currently ranked the fifth leading cause of global disability (health loss). 1 Health status or health-related quality of life (HRQoL) is a clinically important measurement of disability among patients with COPD for prognostic studies and trials.
Similarly, ORR values among patients with poor prognostic factors in trial CA024 also corresponded to the trends in the ITT population.
Different molecular types of breast cancers will require separate clinical trials, different prognostic and predictive markers and different therapeutic strategies.
Based on translational data from controlled prospective clinical trials no prognostic or predictive tissue biomarkers have yet been defined in advanced pancreatic cancer.
However, before being widely embraced, further clinical trials on prognostic and/or predictive biomarkers, alone or in combination, are needed to validate their clinical utility, and to realize the goal of personalized treatment for patients with HNSCC.
The use of predicted breast cancer mortality, on the basis of the three prognostic factors, leads to trials that are substantially smaller and shorter, for the same power, than trials based on observed mortality.
It is conceivable that young patients with HL and poor prognostic features may enter trials in preference to those with lower-risk disease and indeed many clinical trials focus on those patients with poorer-risk disease (Hudson et al, 1993, 2004; Hutchinson et al, 1998; Friedmann et al, 2002).
