Exact(3)
This motif is present in GTs known to be aided by auxiliary proteins and may be a prognostic trait of such GTs.
Several studies have reported that a poor performance status is an adverse prognostic trait (Escalante et al, 1996; Sanz et al, 2002; Talcott et al, 2004; Klastersky et al, 2006).
We found that the extent of activation of the hypoxic response as measured by Hif-1 α immunoreactivity is a prognostic trait that qualifies metastatic behaviour in primary PCC/PGL tissue independently from other adverse histological features, such as capsular invasion or tumour volume.
Similar(57)
However, the level of statistical significance achieved for the prognostic traits tested in our series leaves little doubt about the reliability and reproducibility of our findings.
Variations between our results and those previously published maybe explained by the renown heterogeneity of CUP which may explain the variability in assessing prognostic traits.
In this context, previous studies have identified clinicopathological features such as larger tumour size, the presence of lymphovascular (LVI) (Lopez Guerra et al, 2013) or visceral pleural invasion (VPI) (Fibla et al, 2012) as adverse prognostic traits in early-stage NSCLC.
The systemic effects of cancer-related inflammation can be easily quantified using routinely available blood parameters such as NLR, PLR and mGPS, all of which have been explored as prognostic traits in NSCLC (Forrest et al, 2005; Arrieta et al, 2010; Tomita et al, 2012).
It is not well known, however, whether genetic traits also influence prognostic features of the malignant phenotype.
This lack of clear association with complex phenotypic traits represented by prognostic factors such as tumor grade or with patient outcome is intriguing given the range of potentially important signaling pathways and proteins that Jab1 influences.
The data we consider thus represent a valuable resource for establishing the relative prognostic value of numerous phenotypic traits, and for identifying indices of variables that best predict long-term survival, which may lead to standardized criteria to characterize the phenotype that precedes successful aging.
NHHSMM is concluded as the preferable option as it provides much less volatile predictions and more importantly is characterized by confidence intervals which shorten as more data come into play, an essential trait of a robust prognostic algorithm.
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