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Traditional prognostic classifiers from heterogeneous clinicopathological patient groups have failed to provide a robust signature predictive of outcome in ER-negative breast cancer for which prognostic signals seem to be much weaker (Teschendorff et al, 2007).
However, none of the reported genes were among our 244 discriminators, which may not only be because they were established in a set of leiomyosarcomas using different approaches whereas our signature was established in a larger mixed series of pleomorphic primary STS, but also due to the difficulties in identifying prognostic signals which are considerably weaker than the diagnostic ones.
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Indeed, the combination of hyperlactatemia with pCO2-related markers of tissue hypoxia provides a stronger prognostic signal than either one alone [8].
Fitness estimation may be inaccurate in patients with CHD, could result in individual patients being inappropriately assigned to a specific CRF category and, attenuate any prognostic signal [8].
This implies that "the prognostic signal" is present in both the FF and the FFPE material and as such, the reverse must also be true.
Exclusion of the leiomyosarcomas and liposarcomas that formed subclusters within C was done in order to detect the more subtle prognostic signal among the most pleomorphic samples (Table 1).
High levels of expression of c- erbB-2 (HER-2/neu), and the homologous c- erbB-1, is a poor prognostic sign, and signaling from these receptors occurs in part through p44/42 MAPK.
"That's a good prognostic sign," Krakow said.
However, the prognostic significance of signal intensity changes remains controversial.
Clinical decision making is, however, largely based on prognostic factors that signal the need for care or service planning.
Baseline TGF β provided signals of prognostic effect.
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