Exact(7)
We found no meta-analyses in a prognostic setting of C reactive protein or exercise.
In both the diagnostic and prognostic setting, estimates of probabilities are rarely based on a single predictor.
In both the diagnostic and prognostic setting, estimates of probabilities are rarely based on a single predictor (Riley et al, 2013).
In the prognostic setting, predictions can be used for planning lifestyle or therapeutic decisions based on the risk for developing a particular outcome or state of health within a specific period (Steyerberg, 2009; Moons et al, 2009b).
In the prognostic setting, predictions can be used for planning lifestyle or therapeutic decisions based on the risk for developing a particular outcome or state of health within a specific period.
The decision to administer or not to administer a treatment against some disease is frequently based on an estimated probability p i that an individual i has the disease (or – in a prognostic setting – will develop the disease), typically obtained using a prediction model in the broadest sense.
Similar(53)
It has been shown [14], [15] that if a training set of ∼100 early breast cancer samples is used to rank ∼10,000 genes (by their correlation with outcome), and the ∼100 top genes are selected as the prognostic set, repeating the procedure (with a different set of training samples) will produce a new gene list, whose overlap with the first one is typically 2 3%.
Another common prognostic set of interest is response to BRCA1 expression (MCM513), which many studies have shown a characteristic of sporadic basal-like cancers.
The summed scores for each patient ranged from 0 3 (good → poor prognosis) and, to establish a prognostic model, was dichotomised into a good prognostic set, 'Signature A' (incorporating scores 0 and 1), and a poor prognostic set, 'Signature B' (incorporating scores 2 and 3).
Consequently, newly published signatures in the future can be perceived in the light of well-known modules, and a new, equivalently prognostic set of markers can be devised based on subsets of these lists.
Because results were not stratified by tumour type (40 of 52 tumours were invasive ductal carcinoma), this study does not permit a definitive conclusion to be drawn about whether this prognostic set of three genes will be equally valuable in all breast cancer types.
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