Furthermore, the tumor material allowed us to study prognostic features, relations with different clinicopathological parameters, and associations with CCND1 amplification, in different subgroups defined by the expression of the 11q13 and distal 11q gene products.
In light of these morphological and statistical findings, Cdc20 and securin seem to be potential prognosticators for clinical pathology, although the present data does not yet allow testing for their prognostic value in relation to the gold standard of breast cancer prognostication, the Nottingham Prognostic Index (Elston and Ellis, 1991).
Cox multivariate analysis was used to determine whether VDAC1 is an independent prognostic variable in relation to 7 clinical variables: age, gender, stage, histology, tumour size (pT), nodal stage (pN) and survival.
Winstanley et al (1991) showed the independent prognostic effect in relation to OS.
It should be addressed in future studies, whether PA28γ is of prognostic value with relation to pathogenesis in RA.
Often no correlation is found between promoter methylation and protein expression and both can have prognostic significance in relation to survival of patients treated with TMZ for GBM.
The observed protein expression levels were analyzed for co-expression, for correlation to clinicopathological parameters and for prognostic value in relation to disease-free survival and overall survival.
Loss of HLA class I is important in ovarian cancer prognosis but its role as a prognostic indicator in relation to therapy remains unproven.
This is entirely consistent with our finding of a more positive prognostic outcome in relation to cancers with increased SnoN expression.
Many retrospective studies have identified patterns of biomarker expression before or after chemotherapy which have predictive or prognostic significance in relation to different clinical endpoints.
