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Despite such complexity, a nearly 15 years long examination of breast cancer transcriptome profiles resulted in substantial contributions into subtyping and assessment of the prognostic (providing information on the likely outcome of the cancer disease in an untreated individual) and predictive (providing information on the likely benefit from treatment) value of gene signatures.
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Online fault diagnostics and prognostics provide critical health information for the self-aware building and decision making which will play an important role in the Industry 4.0 factory [11].
The current study gives detailed information on the CRBN-binding proteins expression levels in different clinical and prognostic subgroups providing a functional link between previously reported positive regulation of MYC by IKZF1 and IKZF3 and MYC activation in hyperdiploid MM.
The new prognostic score provided a desired predictive accuracy.
These results confirm the prognostic information provided by BNP determination and suggest that serial measurements give additional prognostic information.
The dlPFC-PL prognostic predictor provides an optimal specificity and sensitivity trade-off (Youden index = SP + SN-1: SP/SNd0 = 1/0.73; SP/SNd1 0.91/0.82) close to the clinically important specificity-optimized (SPmax) cut-off, which maximizes the detection of nonremitters.
The prognostic information provided by GDF-15 was independent of clinical characteristics and clinical risk scores.
The discordance in SPECT and radionuclide angiography results may represent incremental diagnostic and prognostic information provided by both studies.
The fully prognostic mode provides "state-of-the-art climate prediction and analysis tools" (Vertenstein et al. 2012).
CONCLUSIONS: Current prognostic classifications provide modest discrimination of outcomes in mCRPC receiving docetaxel-based chemotherapy, highlighting the need for improved risk-based models.
Second, identified prognostic genes provide insights into the biology of tumor and potential therapeutic targets.
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CEO of Professional Science Editing for Scientists @ prosciediting.com