Myometrial invasion and heterologous elements seem to be principle prognostic factors[ 26].
In principle, more prognostic groups can be constructed, reflecting a division more meaningful from a medical point of view.
The model for tCK18 (but not cCK18) separated the prognostic/PD interaction from the pure prognostic effect, illustrating the principle of dual prognostic and PD characteristics for a given biomarker.
The development of a multivariate prognostic model is based on principles and methods described by Moons and Altman et al. [ 66- 69].
40 More broadly, across clinical specialties we propose that professional societies and government policy forming bodies such as NICE should consider cost effectiveness in evaluating prognostic biomarker strategies using similar principles as they do for drug, device, and other technologies.
Genes with the greatest prognostic power were identified using supervized principle components analysis [ 23] using version 3.5 of BRB ArrayTools [ 24] as previously described [ 12].
In the present studies we have investigated the dynamics of clearance of mycolactone from skin tissues during curative antibiotic treatment in order to provide proof-of-principle data on the prognostic potential of mycolactone as a biomarker.
In other words, in diagnostic prediction, the interest is in principle a cross-sectional relationship, whereas prognostic prediction involves a longitudinal relationship.
23 An ethical imperative to open prognostic disclosure and early EOL discussions is the principle of patient autonomy; that patients have the right to information about their body and to contribute to decisions about their medical care if they wish.
53 RXA-GSP is built on three principles: 1) each individual has both favorable and unfavorable prognostic factors for breast cancer.
