Acknowledging practical, financial, and ethical reasons why this approach is so favoured, they emphasise that long-term prospective trials would be useful to inform the prognostic interpretation of the IGRA.
It is likely a more nuanced diagnostic and prognostic interpretation of truncating mutations will be needed.
The identification of VOUS in prenatal testing is challenging and disturbing, since a clinical and prognostic interpretation is required.
Interpretation of prognostic studies should consider biases related to differential inclusion of nonrepresentative samples of patients, poor measurements of outcomes, and poor control for confounders.
Determinants of selection and their implications for generalisability and interpretation of prognostic findings need to be reported.
Holländer and Sauerbrei (2006) showed that the choice of statistical method has a strong influence on the results and, therefore, on the interpretation of prognostic marker studies.
The interaction of the components of pHi and their response to treatment may confound the interpretation and prognostic relevance of gastric mucosal acidosis.
Differences between the microarray datasets, varying outcome information, and incomplete control of confounding by prognostic factors may limit interpretation of these findings; however, we attempted to control for patient and tumour heterogeneity between these studies by performing two analyses: a random-effects and a fixed-effects meta-analysis.
However, one should emphasize that most studies of neuroimaging for CA patients are limited by their retrospective nature, heterogeneous populations (for example, not all patients were comatose), and the self-fulfilling prophecy of early withdrawal of life-sustaining therapy (that is, the falsely pessimistic interpretation of prognostic variables concurrently used to forgo life support) [ 77].
Rather, our goal was to examine the utility and prognostic significance of two different interpretations of a currently well-established frailty measure - elements of which may provide simple and practical screening tools for clinical purposes [ 19, 32].
