The prognostic component of the ER and ERBB2 status as well as different gene signatures were found to be strongly related to tumor proliferation.
On the other hand, a prehospital evaluation scale would be optimal if (apart from being descriptive) it had a prognostic component, and would therefore be applicable to hospital-based observation of the patient.
Predictive biomarkers can encompass both prognostic and predictive components, a phenomenon which may hamper the detection of a beneficial effect from treatment, unless the prognostic element has been investigated and mapped [ 15].
It has also become apparent that the most important prognostic and predictive component of these first generation assays comes from their ability to measure proliferation reproducibly and quantitatively [ 6].
In uterine neoplasm with a sarcomatous component the most important prognostic factor generally is the stage[ 11, 20, 36- 38].
This suggests that in addition to the strong performance of BCI as a prognostic, its components may also have predictive properties.
However, high-risk worst pattern of invasion (WPOI), a component of HRS, was also an independent prognostic factor (HR, 4.47; 95% CI, 1.59 12.51).
Differentiation grade turned out to be a very valuable independent prognostic factor and should be incorporated as a routine component of the histopathologic reports in vulvar cancer.
