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By computing the Pearson correlation coefficient of the expression values of these genes and the centroids of the original good prognosis template [17], a prognostic class can be assigned to each sample.
The clinical outcome of these patients, i.e. their prognostic class, was evaluated after 30 days post-MI by means of the ejection fraction (EF).
In the meantime, microarray-based and proteomics data profiling genes, mutations, and interacting oncogenic signaling pathways may lead to the development and validation of both biologically targeted agents and prognostic class II and predictive class III biomarkers.
However, as previously shown [ 5], the best candidate gene-expression prognostic markers can also exhibit bimodal (or multimodal) profiles (ie, mixtures of Gaussians) within a given prognostic class, indicating that these phenotypes are themselves heterogeneous and that classification analysis should attempt to take this heterogeneity explicitly into account.
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Gene expression profile (GEP) testing segregates uveal melanoma (UM) into 2 main prognostic classes.
* from breast cancer diagnosis to brain metastases The 3 other scores contain 4 prognostic classes each.
This model was shown to significantly classify doxorubicin-treated breast cancer patients into distinct prognostic classes.
The training set cases were grouped into two different prognostic classes.
Figure 2 illustrates the difference in nuclear texture between the two prognostic classes.
It comprises three prognostic classes based on Karnofsky performance status, age, and control of extracerebral disease [ 13].
The other score with 3 prognostic classes is the SIR, which could be assigned in 54 cases.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com