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Additionally, we evaluated the prognostic behavior of lowering the ki67 cutoff in the ER+PR+HER2- group (820 patients).
Ladoire et al. in their series of HER2+ over expressing breast carcinoma found that the presence of FOXP3 Treg infiltration had no prognostic behavior [ 30].
The distinctions in prognostic behavior of the signatures with respect to ER status suggest that different molecular mechanisms are involved in risk stratifications within each ER stratum.
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Breast cancer is a heterogeneous disease composed of different intrinsic subtypes, each with distinctive biological and prognostic behaviors and responses to therapy.
To study the clinical and histopathologic features of cutaneous eyelid melanomas and identify prognostic factors in the behavior of such tumors.
This explains why the Hakka subjects were diagnosed in the early stages, and that better medical behavior grants prognostic improvement.
Clinical behavior and prognostic features of soft tissue sarcoma are known to be associated with histology, and anatomic distribution.
2, 3 This study analyzes prognostic factors predicting metastatic behavior and survival outcome starting with the time of first relapse at different anatomic sites.
This was the case also for our set of patients, suggesting that use of CD44 as a single prognostic marker of CRC behavior is impossible.
Still, it cannot be excluded that ex vivo drug sensitivity is only a prognostic marker reflecting tumor behavior unrelated to a therapeutic effect from IPC.
An attempt to account for the biological behavior and prognostic relevance of certain tumors is reflected by grade and bulk as introduced by the Cotswold modification [ 9].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com