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Hence, miRs expression profile analysis enables us to predict prognosis, support diagnosis, and improve therapy responses in cancer [ 19, 25].
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In multivariate analysis stathmin represented a significant independent marker of worse prognosis (Supporting Information Table S6).
Expression in some studies is associated with microvessel density and prognosis, supporting the importance of VEGF-A in human malignancies.
The correlation between tumor PD-L1 expression and prognosis supports the hypothesis that this molecule may serve as a predictive biomarker.
In women, breast cancers with a macrophage infiltrate have a poorer prognosis, supporting the hypothesis that macrophages are promoters of breast cancer [ 56].
The findings of the present study suggest that a low peak xylose concentration in absorption testing is associated with a less favourable prognosis, supporting the use of this test.
For instance, Pauletti et al (2000) found that the maximum number of copies of HER-2/neu in breast cancer cells correlated with the worsening of the prognosis supporting that this is a good index for assessing amplification.
In contrast the association between AP-2α and ER is weaker and patients with this profile do not have such good prognosis, supporting a tumour suppressor role for AP-2β.
Comparing survival of patients undergoing negative PALN identified by surgical staging to patients with only radiographic exclusion of PALN metastases, Gold et al (2008) showed that patients with radiographic evaluation only had a poorer prognosis supporting the therapeutic effect of lymphadenectomy.
The initial response to anthelmintic and corticosteroid therapy could be a useful prognostic indicator, and the findings of the present study suggest that a low peak xylose concentration in absorption testing is associated with a less favourable prognosis, supporting the use of this test.
While either active WNT signaling or FGFR1 amplification/overexpression is associated with poor disease-specific survival (Fig. 1a and b), tumors with both pathways activated exhibited the worst prognosis, supporting that the two pathways may cooperate to drive tumor progression in human breast cancer (Fig. 1c).
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