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Finally, multivariate Cox proportional hazards regression modelling was applied to assess independent prognosis effect for RFS.
Among the MSKPN individual prognostic variables 15, histology and tumor size showed significant prognosis effect in our data.
In contrast, the anti-proliferative activity of MCL-1 and BCL-2 is associated with a favorable prognosis effect in some early carcinomas, such as lung adenocarcinoma [ 18].
The "poor prognosis" effect of PIK3CA mutations seemed to be robust and consistent across most strata of clinical and tumoral predictors of patient outcome, but this effect seems to be limited to patients with KRAS wild-type tumors [ 22].
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We have shown that Citizen Scientist scoring of breast cancer cores is sufficiently accurate to detect an association between ER status and prognosis, with effect sizes only slightly attenuated compared to the effects estimated from clinical data.
He, X. et al. HLA-G expression in human breast cancer: implications for diagnosis and prognosis, and effect on allocytotoxic lymphocyte response after hormone treatment in vitro.
We review the literature on (i) the specificity and heterogeneity of ILC biology as documented by various analytical techniques, including the results of molecular testing for risk of recurrence; (ii) the impact of lobular histology on prediction of prognosis and effect of systemic therapies in patients.
Pathological assessment based on the histopathological investigation of resected specimens is important for estimating the prognosis and effect of radiochemotherapy [ 6, 7].
Notice that when the seventy gene signature has a poor prognosis, the effect of CSR correlation on survival is also magnified.
Poor pre-treatment PS, the presence of liver metastasis and high DNA Index were shown to be associated with adverse prognosis; the effect of HP infection status on survival has yet to be defined.
The overall impression is that whilst EGFR mutations are associated with a better prognosis, this effect is not independent of the other good prognostic factors with which this mutation is associated.
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