Invariably, the Ura+ progeny grew poorly and displayed morphological defects (Fig. 1B).
Yet, the precise developmental window at which cTECs and mTECs diverge, as well as the lineage relationship between TEPs and the emerging cortical and medullary progenies, remain poorly understood.
However, their precise molecular relationships and the mechanisms underlying the differentiation of these progeny cells are poorly understood.
This situation has biosafety implications regarding the unintended spread of novel transgenes, and risk assessments of crop-wild hybrids often assume that poorly adapted hybrid progeny will not evolve adaptive phenotypes.
Bax−/− progeny have varying coat color, are poorly pigmented and have pink eye because the coat color loci tyrosinase (Tyr) and pink-eyed dilution (p) are linked to the Bcl2-associated X protein (Bax) gene.
Furthermore, although this subpopulation increased following long-term random breeding of the mouse line, blood testing is also used to monitor PrPc expression levels during breeding in order to eliminate those breeders that produce progeny with a high proportion of poorly expressing animals.
Recent experiments in mice show that both TCM and TEM cells can arise from activation and proliferation of the TCM compartment, whereas TEM cells are more terminally differentiated and therefore proliferate poorly and only give rise to TEM progeny [23].
The malaria parasite Plasmodium falciparum replicates within erythrocytes, producing progeny merozoites that are released from infected cells via a poorly understood process called egress.
The cell lines used in the present study include the GFP-transfected parental, poorly metastatic MDA-MB-468GFP (468GFP) cell line and a progeny MDA-MB-468GFP-LN (468LN) cell line variant that is highly tumourigenic and that also maintains a propensity to metastasize in a mouse xenograft models.
This is in agreement with Frascaroli et al. (2009) who compared QTL detection on related and unrelated test-cross progenies and concluded that for traits characterized by prevailing dominance overdominance gene action (such as grain yield) the poorly performing inbred parental line was the most effective tester for QTL detection, whereas the unrelated tester was the least effective.
