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At the peak of infection, the tissue sections obtained from the Querétaro group had intense interstitial inflammatory infiltrate with profuse cells on muscular fibers with granulomatous-like infiltrates, as well as disorganization and myofibers necrosis).
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Osteocytes are the mechano sensors and the most profuse cell type in adult bone (Mullender and Huiskes 1997).
The cyst wall produced an enlarged tumor with profuse growth of cells with nuclear atypia.
We found that AQP4 immunoreactivity was profuse on glial cells bordering ventricles, blood vessels, and subarachnoid space.
In contrast, mice with CIA showed severe cartilage and bone and erosion and profuse infiltration of inflammatory cells.
Ultrastuctural analysis revealed that MCF7 cells showed profuse autophagy activation with none or minimal cytosolic inclusions, whereas MCF10A cells presented aggresome-like structures, without evidence of autophagy activation.
Anxa6 knockdown cells have profuse fragmented mitochondria even in the absence of PE treatment and the percentage of fragmented mitochondria gradually increased with the duration of PE treatment.
A profuse perivascular network of GFP+ cells can be observed, mostly associated with arterial blood vessels.
We agree that the significance of the main finding of our work that the iNC axons target the GABAergic Golgi cells in a profuse and strong manner may have led to the lack of discussion regarding other possible targets of the iNC axons.
These findings seem to be specific for this particular cell line, and we demonstrate that despite lysosome dilation with chloroquine treatment, this profuse lipid accumulation is not seen with NIH 3T3 cells, neuroblastoma or glioblastoma cell lines that we have tested.
The early stage, characterized by ductal lengthening and profuse branching, is sustained by active cell proliferation at the distal end of the ductal tree.
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