How PDA cells survive such a profoundly hostile microenvironment is worthy of study in its own right but likely includes a reliance on alternate metabolic pathways (Roberts and Borges, 1955; Warburg, 1956), transient microregional variations in pressures and blood flow (Heldin et al, 2004), and autophagy (Yang et al, 2011), among other possibilities.
Mr. Lindo's performance gives the worthy CBS film "Profoundly Normal" its complexity.
One of the reasons Spinal Tap still bangs after all these years was its ability to so profoundly make fun of metal, while simultaneously delivering songs worthy of serious headbanging.
But Kander & Ebb gave her a gift already worthy of this legend and Rivera capitalizes on that profoundly.
A Death in the Family begins with a grand meditation on post-mortem microbes worthy of Jim Crace's Being Dead, and ends impressively too, with a profoundly resonant last line.
At its best (Seasons 2-4), The Office encapsulated the awkward, frustrating, and often cringe-worthy moments of the workplace in a manner that was both profoundly funny and often just profound.
But in a wayward world, when there is consensus among journalists, critics, and cultural commentators that something is worthy of scorn, this is a sure sign that there is almost certainly something profoundly valuable about it.
The Victorian worthies had not just been hypocrites, they had bequeathed to Strachey's generation the whole "profoundly evil" system "by which it is sought to settle international disputes by force".
But his bold idea is one of many trying to profoundly change transport as we know it, from cars controlled remotely by a robot truck to road-worthy vehicles with folding wings that allow it to fly.
Profoundly Loved, Profoundly Missed.
