Although it remains possible that mqPOP2 may more profoundly inhibit other specific inflammasomes or exhibit species specific inflammasome inhibition, these results demonstrate that mqPOP2 possesses the identified functions of its human ortholog.
C-myc contributes to hepatocarcinogenesis not only by regulating cell proliferation and death but more profoundly by modulating specific metabolic pathways [ 45].
The effect of FCS alters more profoundly the pathogen specific reaction norm of the pbMEC than challenging them with either live or heat killed pathogens.
Despite being small (~22 nt) microRNAs (miRNAs) profoundly influence tissue-specific gene expression by interacting with complementary target sequences in cellular messenger RNAs, impairing their translation or marking them for early destruction.
Efficient clearance of apoptotic cells (efferocytosis) can profoundly influence tumor-specific immunity.
Here, we report that ROQUIN has a paradoxical function on Tfh differentiation mediated by its RING domain: mice with a T cell-specific deletion of the ROQUIN RING domain have unchanged Th1, Th2, Th17, and Tregs during a T-dependent response but show a profoundly defective antigen-specific Tfh compartment.
Reading her proposal, he found her storytelling to be specific yet profoundly universal.
Thus, 19th century archaeological research and historical interpretation did not occur in a vacuum; rather, they were profoundly shaped by the specific policy goals of the regime in power and were forced to adapt to the vicissitudes of the changing political environment.
Even though this is a site-specific project, profoundly rooted in the history of a place, it is also an opportunity for the student to develop a personal agenda, which ultimately should be the goal of the last advanced studio.
The chemical composition and biophysical characteristics of extracellular matrices used in hepatocyte cultures profoundly affect both liver-specific gene expression and cellular response to extracellular soluble signals.
Our results provide a straight forward assessment of the relationships between intrahost viral fitness, virulence, and vectorial capacity which demonstrates that arbovirus adaptation and evolution could be profoundly influenced by strain-specific effects on life-history traits and transmission potential of mosquito vectors.
