Sentence examples for profoundly perturb from inspiring English sources

Air liquid interface cultures are useful models for studying airway biology, but the present findings indicate that, despite phenotypic similarities with primary cells, these culture systems profoundly perturb miRNA and gene expression.

In this study, we show how gross changes in the bacterial environment, such as the onset of infection, can profoundly perturb the sociomicrobiological structure of the bacterial population, driving a minor subpopulation with a mutant hypervirulent phenotype to thrive, prevail, and cause severe disease.

This persistence of Nanog expression seems to profoundly perturb the commitment of p53−/− ESCs.

This amino acid substitution has recently been documented to profoundly perturb intracellular signaling [Chen et al., 2010].

HSCT has been shown not only to affect B-cell populations, but also to profoundly perturb the T-cell compartment, as illustrated by the normalization of the deregulated T-cell-receptor repertoires in multiple sclerosis [ 37].

In summary, we propose that 1q12 anomalies correspond to a new class of chromosome rearrangements with the power, via novel long range heterochromatin-dependent mechanisms, to profoundly perturb gene organization and function in lymphoma.

Remarkably, the absence of microbiome in germ-free mice had a time and sexually dimorphic impact both prenatally and postnatally: microglia were more profoundly perturbed in male embryos and female adults.

We and others have shown that GMAP210 co-sedimented with taxol-purified MTs [ 11, 12] and its over-expression profoundly perturbed, not only GA structure and function, but also MT-network organisation [ 12].

Blocking KAP1 recruitment via mutagenesis would require the fine mapping of KAP1 recruiting site and their deletion or mutation, which for close to 30 such sites detected on the HCMV genome is not only daunting but unlikely to be possible without profoundly perturbing other features essential to the virus.

This is likely to have a direct relevance to the way in which human Scrib can similarly restrain an oncogene-mediated transformation and, more generally, on how the outcome of oncogenic signalling can be profoundly perturbed by defects in apico-basal epithelial cell polarity.

That understanding could help us think more clearly about how to manage the impact we are having on our planet's biogeochemical system, which we are currently perturbing at least as profoundly as the factors behind some of the great mass extinction events in its history.