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One reason for the invitation to doubt extended by Neo-Confucians seems to have been their realization that many Neo-Confucian tenets, especially metaphysical ones, were profoundly novel.
This rapid and unique response suggests a profoundly novel and effective vascular-occlusion mechanism, outlining the Tookad-VTP-specific targets and mode of action.
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But this is still an intelligent and profoundly unsettling novel.
It is a profoundly touching novel in dialogue that makes powerful statements about Latin American culture.
This profoundly moving novel reminds us that he is still the most trustworthy and rigorous prose writer of our age.
It is a profoundly disturbing novel, suffused with a weird and unsettling poetry, that asks deep questions about healing and harming.
Lily argues effectively for nonrepresentational but emotive art, and her painting (in which mother and child are reduced to two shapes with a line between them) echoes the abstract structure of Woolf's profoundly elegiac novel.
She wrote four novels before In Certain Circles that were highly praised at the time; the Sydney Morning Herald called 1966's The Watch Tower "a dense, profoundly moral novel of our time".
When I suggested to the group in Edinburgh that maybe, possibly, To Kill a Mockingbird might be considered a profoundly racist novel there was a collective sharp intake of breath and some very stony stares.
This book, too, is an intimate and profoundly realistic novel of family life and close relationships, with a triangle of characters at its heart who compare themselves with the characters in Tolstoy's War and Peace.
Combining as it does the cultural narrative of a complex century forsaken by God and certainty, a serious investigation of the vulnerability of the human mind and an old-fashioned – in the best sense – story of love and war, this is an ambitious, demanding and profoundly melancholy novel.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com