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"profoundly low" is grammatically correct and can be used in written English.
It is used to describe something that is extremely or deeply low in a certain aspect. Example: The country's economy was profoundly low, with unemployment rates reaching record lows and many struggling to make ends meet.
Exact(11)
It was a profoundly low and debasing moment in American political life.
And while transgender people approach their transitions differently, the number of existing providers equipped to care for me and others remains profoundly low.
Given that the series seems intended to pull back the blankets on the "real" side of both politics and media — two professions held in profoundly low regard by the rest of the world — we thought it might be fun to go argue about what the series gets right and wrong.
Interest rates already rest profoundly low in their 60-year history as do mortgage rates.
These included the nightshift of 5 July 2011, when Beryl Hope, 70, was found by the morning shift to be unresponsive, sweating and had "profoundly low" blood sugar levels - evidence of insulin poisoning.
Other similar studies also have showed profoundly low resistance rates among bacteria to vancomycin [ 8, 14, 28, 31].
Similar(49)
The sensitivity is reduced in the dual-task condition more profoundly at low temporal frequencies.
However, it is desirable to obtain mutants that react profoundly to low amounts of light, but have in darkness a tight association of the helix to the core domain.
He was profoundly depressed.
Our city feels profoundly O.K. and profoundly broken.
A few were profoundly depressed.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com