'profoundly disrupt' is a correct and usable phrase in written English.
It is used to describe a situation where something causes something else to become significantly changed or upset. For example, "The announcement of the new policy profoundly disrupted the daily routine of the office."
These extinctions will profoundly disrupt the food web for people over the entire Earth.
Alterations that occur in uremia profoundly disrupt this intricate system of regulation.
The changes are primarily focused on automating activities rather than individual jobs, but the scale of those changes is likely to profoundly disrupt what sales people do.
"It is both illegal and deeply unethical to use techniques that profoundly disrupt someone's personality," Leonard S. Rubenstein, the executive director of Physicians for Human Rights, an advocacy group that has been critical of the Bush Administration, says.
And while the shortage affects the entire state court system, in Family Court, the quality of legal representation -- and delays in getting any representation at all -- can profoundly disrupt children's lives.
For many women, the monthly suffering induced by menstrual "cramps" is severe enough to profoundly disrupt their quality of life.
However, in others it has profoundly disrupted high-stakes testing.
Meanwhile, though, air service to Egypt remains profoundly disrupted.
Multiple sclerosis (MS) patients commonly suffer from fatigue and define it as one of their most disabling symptom profoundly disrupting their lives.
It was charting, through the metaphors of sci-fi, the psychological reality of a society being profoundly disrupted by technology that made Gibson's writing exceptional.
But there is no doubt that we now live in a world where the power of capital has profoundly disrupted old ideas about political authority inside national boundaries.
