Exact(2)
Sadistic parents have a profoundly deleterious effect, as do siblings and other close relatives.
The somatic mutation occurs within a region of the D-loop, which encompasses the origin of H-strand replication, the light-strand promoter and a binding site for mitochondrial transcription factor 1. This suggests that the base alteration at np 438 may have a profoundly deleterious effect on mitochondrial function.
Similar(58)
The initial effect of incorporating T3 gene 10 did not appear to be profoundly deleterious: the fitness immediately after transgene insertion was 30.5.
Previous studies that showed strong inhibition of HIV-1 replication after efficient knock-down [38], interaction between HIV-1 Tat protein and PDE8A [89], [89] and the deleterious effect of high levels of cAMP on HIV-1 replication [90], all profoundly suggest that this type of phosphodiesterase is indeed important for in vitro HIV-1 replication.
"Meltwater can have a really deleterious effect," said DeConto.
Clinical studies show that methadone has no deleterious effect.
It has had a deleterious effect on the natural environment".
Not one, but two illnesses in the camp have had a deleterious effect on the team.
To be sure, the war had a deleterious effect on the art of Braque.
The mass influx has also had a deleterious effect on the site.
But the evidence that the internet has a deleterious effect on the brain is zero.
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