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Additionally, and also relatedly, his profoundly deficient attention makes it impossible for him to focus on any stimuli that do not provide him with adulation.
Consistent with previous studies[7], [22], the αCaMKII+/− heterozygous mutants show nearly normal short-term (STM test), but profoundly deficient remote (RM test), memory (Figure 2, red bar).
This is essential for ATF2 phosphorylation, which is profoundly deficient in Lrh-1 LKO hepatocytes in response to stress.
BAFF-deficient mice are profoundly deficient in B cells, whereas BAFF transgenic mice have increased B cell numbers and develop a lupus-like syndrome [ 10].
In addition, single cell electrophysiological measurements were consistent with compromised post-synaptic events in neurons from the profoundly deficient cell line, although further analysis is needed to confirm this observation.
If critically ill patients are profoundly deficient in vitamin D due to increased tissue requirement for this pleiotropic hormone for immune defence and metabolic regulation, does vitamin D treatment improve outcome?
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Of note, his younger sister has a very adequate cortisol response to synacthen stimulation at one month of age, but was profoundly cortisol deficient by one year.
During this period of 8 14 weeks post-conception, transfer of maternal cortisol across the placenta seems of secondary importance to fetal adrenocortical production; female fetuses with congenital adrenal hyperplasia due to 21-hydroxylase deficiency would otherwise not be so profoundly cortisol-deficient as to virilise [ 31, 32].
Everyone else is profoundly inferior".
Rabbi Eric Yoffie, the president of the Union for Reform Judaism and a natural ally, writing in a more-in-sorrow-than-in-anger op-ed in The Forward, described Luria's sentiments as "morally deficient, profoundly out of touch with Jewish sentiment and also appallingly naïve".
This may be explained by the small proportion of participants who were profoundly vitamin D deficient (n = 310, 2.89%).
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