Sentence examples for profoundly defective from inspiring English sources

Reflecting this, the absence of MMP-8 led to a profoundly defective PMN infiltration response in vivo to LPS or to full-length LIX, CXCL8, and CXCL5.

Further studies in man indicate that renal transplant recipients at risk of invasive fungal infections also have profoundly defective TNF-α expression (Armstrong-James et al, 2012).

Males lacking fruM appear to be externally normal males yet are profoundly defective in most aspects of courtship behavior [ 8 10].

Here, we report that ROQUIN has a paradoxical function on Tfh differentiation mediated by its RING domain: mice with a T cell-specific deletion of the ROQUIN RING domain have unchanged Th1, Th2, Th17, and Tregs during a T-dependent response but show a profoundly defective antigen-specific Tfh compartment.

However, ER homeostasis can be profoundly disturbed by defective post-translational protein modifications and the accumulation of misfolded or viral proteins, all of which activate the UPR pathway in the ER.

These papers are phylogenetically profoundly wrong and conceptually defective in failing to be cell biologically or evolutionarily realistic.

Previously, we have shown that the rate of frameshifts at microsatellites increases profoundly in mismatch-repair-defective Caenorhabditis elegans and human cells, using a similar type of microsatellite instability reporters (Koole et al., 2013; Pothof et al., 2003).

Several studies reported that multiple components of the ATR pathway such as CHK1 [ 44], HUS1 [ 45], and Claspin [ 46], or other ATR substrates, profoundly affected CFS integrity when defective.

For instance, like human USH1g patients, the Ush1g-defective mouse model Js is profoundly deaf with vestibular dysfunction; however, unlike human USH1g patients, it does not have abnormal retinal phenotype [ 58].

Notably, B-cell precursors from infant patients with pro-B cell leukemia have markedly reduced SYK activity due to expression of defective SYK proteins with a missing or truncated catalytic kinase domain coded by profoundly aberrant mRNA species (Goodman et al., 2001).

Profoundly Loved, Profoundly Missed.