Sentence examples for profoundly contributed from inspiring English sources

This review describes how recent technological advances have profoundly contributed to our current understanding of the genetic architecture and the epigenetic rules controlling immune responses to infectious agents and how genetic and epigenetic data can be combined to unravel the mechanisms associated with host variation in transcriptional responses to infection.

C. elegans is a primary model organism for aging studies and has profoundly contributed to the determination of genetic and environmental factors that affect aging in organismal level.

Peripheral IL-6 trans-signaling appears to more profoundly contribute to sleep regulation, mainly by supporting SWS.

Finally, after many centuries of discord powerful accomplished women leaders and the visionary men who are their heroes are beginning to gather together in a way that honors both genders and encourages each to profoundly contribute to the other.

Cytokine expression in the microenvironment of evolving lesions can profoundly contribute to plaque development.

A link between MCs and skin barrier defects was recently uncovered, with histamine being found to profoundly contribute to the skin barrier defects.

Recently, a bundle of studies have showed that miRNAs might behave as cancer 'drivers' and the aberrant expressions could profoundly contribute to the progression from premalignant lesion to cancer [ 12- 14].

Altered expression of critical miRNAs, such as miR-146a and miR-155, thus profoundly contributes to the pathogeneses of rheumatic diseases, where dysregulation of their target proteins leads to unabated inflammatory cytokine production and signaling, and aberrant priming of adaptive immune response.

We are sure that the technology-driven O-GlcNAcomics will boom soon, which would profoundly contribute to the elucidation of crucial functions of protein O-GlcNAcylation in versatile physiological and pathological conditions and to a systems perspective of molecular mechanisms in biological networks.

Each theory has contributed profoundly to the acceptance knowledge.

This suggests that dysfunction of proteins assigned to these GO terms contributed profoundly to Rb tumorogenesis.